Mouse Anti-Human CD107b/LAMP-2-BIOT MBS674325 from MyBioSource.com

Product Specs
ItemMouse Anti-Human CD107b/LAMP-2-BIOT
CompanyMyBioSource.com
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberMBS674325
Quantity100 Tests
ApplicationsFlow Cytometry; Immunohistochemistry (Acetone Fixed/Frozen Sections)
Conjugate/TagBiotin (BIOT)
FormatBiotin (BIOT) Conjugate
ReactivityHuman
TargetCD107b (LAMP-2)
IsotypeIgG1
CloneH4B4
HostMouse
Antibody TypeSecondary
ImmunogenHuman CD107b/LAMP-2
CD107b, also known as lysosomal-associated membrane protein 2 (LAMP-2), is a heavily glycosylated, type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion. CD107b is expressed by granulocytes, T cells, macrophages, dendritic cells, activated platelets tonsillar epithelium and some tumor cell lines, including U937 and KG1a. It is also a widely expressed intracellular antigen. LAMP-2 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential, where they may increase adhesion to extracellular matrix and endothelium.1-7
ClonalityMonoclonal